产品货号：
Z15422
中文名称：
EDG1/S1PR1抗体
英文名称：
Anti-EDG1/S1PR1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-EDG1/S1PR1 Antibody |
| 指标别名 | CD363;CHEDG1;D1S3362;ECGF1;EDG 1;EDG1;S1P receptor 1;S1P receptor Edg 1;S1P1;S1PR1;S1PR1/EDG1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | S1PR1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | S1P1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human S1P1.The immunogen is located within the last 50 amino acids of S1P1. |
| 计算分子量 | 43kDa |
| 成分 | S1P1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | S1P1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Movement of lymphocytes through lymphoid organs is required for generating immunity.Their migration into lymph nodes follows a series of events including integrin activation through chemokine signaling,adhesion and diapedis.The release of lymphocytes from lymph nodes is regulated by the phospholipid sphingosine-1-phosphate (S1P).One of its receptors S1P1 binds S1P with high specificity and affinity;agonism of this receptor by the immunosuppressive agent FTY720 inhibits the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions.Recent experiments have indicated that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did and these cells where also less effectively retained after treatment with FTY720,and that egress competence could be restored by inactivating G alpha i-protein-coupled receptor signaling.These results suggest that S1P1 acts in the lymphocyte to promote lymph node egress by overcoming retention signals mediated by CCR7 and G alpha i-protein-coupled receptor signaling. |
| Uniprot ID | P21453 |
| 基因名全称 | Sphingosine-1-phosphate receptor 1 |
| 蛋白名全称 | Sphingosine-1-phosphate receptor 1 |
| 推荐稀释比 | S1P1 antibody can be used for detection of S1P1 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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